German Clinical Trials Register

Acronym/abbreviation of the study

PROVID-CAPSyS

URL of the study

https://www.capsys.imise.uni-leipzig.de/index.jsp

Brief summary in lay language

In the PROVID-CAPSyS study, which is part of the collaborative project CAPSyS (Systems Medicine of Community-Acquired Pneumonia), the course of disease of hospitalized patients infected with the SARS-CoV-2 virus is observed when these patients already require ventilation, i.e. when they have a severe course of COVID-19 disease. The clinical data thus obtained and the molecular parameters measured from biomaterials collected from these patients complement the data obtained in the PROVID-PROGRESS and PROVID-CAPNETZ studies from patients with mostly milder courses of COVID-19 disease. This allows to gain a comprehensive systems medicine understanding of the course of COVID-19 disease and thus to support the development of new prevention and therapy approaches. Our systems medicine approach rests on three pillars: 1) Establishment of the PROVID-CAPSyS cohort of ventilator-dependent patients with severe disease courses, complementing the PROVID-CAPNETZ and PROVID-PROGRESS cohorts with patients primarily in normal wards, to contribute to a comprehensive characterization of different severe disease courses. 2) Conduct targeted interventional animal experiments analogous to our work in pneumococcal pneumonia to establish a detailed data base for mechanistic models; and 3) biomathematical modeling of the disease starting from epidemiological models to describe the disease course of hospitalized patients to models of endothelial barrier failure, corresponding systemic effects and potential novel therapeutic approaches.

Brief summary in scientific language

To improve clinical management of COVID-19 and its complications, there is an urgent need for clinical (e.g. scoring systems) and molecular (e.g. biomarkers) predictors of COVID-19 progression as well as better understanding of disease mechanisms leading to new therapeutic targets. Host- and virus-dependent mechanisms associated with the clinical appearance of COVID-19 are not yet well understood. In the PROVID-CAPSyS study, which is part of the collaborative project CAPSyS (Systems Medicine of Community-Acquired Pneumonia), the course of disease of hospitalized patients infected with the SARS-CoV-2 virus is observed in a severe phase, i. e. when these patients already require ventilation. Clinical data thus obtained and the molecular parameters (transcriptome, proteome, cytokines, clinical biomarkers) measured from biomaterials collected from these patients complement the data obtained in the PROVID-PROGRESS and PROVID-CAPNETZ studies from patients with mostly milder courses of COVID-19. Systematic biostatistical analysis and mathematical modelling will allow to gain a comprehensive systems medicine understanding of the course of COVID-19 and thus to support the development of new prevention and therapy approaches. Our systems medicine approach rests on three pillars: 1) Establishment of the PROVID-CAPSyS cohort of ventilator-dependent patients with severe disease courses, complementing the PROVID-CAPNETZ and PROVID-PROGRESS cohorts with patients primarily in normal wards, to contribute to a comprehensive characterization of different severe disease courses. 2) Conduct targeted interventional animal experiments analogous to our work in pneumococcal pneumonia to establish a detailed data base for mechanistic models; and 3) biomathematical modeling of the disease starting from epidemiological models to describe the disease course of hospitalized patients to models of endothelial barrier failure, corresponding systemic effects and potential novel therapeutic approaches.