Paralinguistic Speech Characteristics in Depression
Organizational Data
- DRKS-ID:
- DRKS00023670
- Recruitment Status:
- Recruiting complete, study complete
- Date of registration in DRKS:
- 2021-01-19
- Last update in DRKS:
- 2023-12-21
- Registration type:
- Retrospective
Acronym/abbreviation of the study
ParaSpeChaD
URL of the study
Brief summary in lay language
In this project we analyse if speech characteristics like rhythm, pitch or loudness differ between depressed and healthy individuals. Therefor we collect different speech probes and analyse them with a software. Furthermore we want to test whether these speech characteristics can also be used in psychotherapy. Participants take part in a short training, in which they are told to uplift their negative mood by using positive statements. Some of the participants additionally receive a feedback regarding their speech characteristics, in order to increase the positive effect of the statements.
Brief summary in scientific language
Major depressive disorder (MDD) continues to be one of the most challenging mental health problems of our time. Although there are established instruments to (a) diagnose and (b) predict MDD as well as effective treatments (c), alarmingly MDD is often not accurately diagnosed. To address these needs Paralinguistic Speech Characteristics (PSCs; i.e. the vocal phenomena that occur alongside the linguistic information in speech) are promising objective markers. However, little is known whether PSCs can (a) diagnose MDD, (b) predict its future course and (c) to further enhance the efficacy of evidence-based interventions against depression. This Project has three main goals. First, we will clarify to what extent depressive symptom severity can be validly assessed with the aid of PSCs (a). Second, we aim to clarify to what extent PSC-based classifiers can predict the course of depressive symptoms over time (b). Third, we will explore to what extent PSCs can be used as a therapeutic target (c). To attain these goals, voice samples will be recorded and analyzed to (a) diagnose and (b) predict DSS and we will experimentally manipulate PSCs in a short training and assess the effects of this manipulation regarding changes in depressive symptom severity.
Health condition or problem studied
- ICD10:
- F32 - Depressive episode
- Healthy volunteers:
- No Entry
Interventions, Observational Groups
- Arm 1:
- In a one hour training patients are trained to use self-referring reappraisal statements to uplift their negative mood. The training begins with a negative mood induction. After that patients read negative statements and react to them with positive statements repeatedly.
- Arm 2:
- Patients are trained to use self-referring reappraisal statements to uplift their negative mood. Additionally they receive a feedback how they can modulate their voice to sound more convincing and increase the positive effect.
Endpoints
- Primary outcome:
- Differences in paralinguistic speech characteristics between depressed and non-depressed individuals
- Secondary outcome:
- Further study goals: - Improvement of the algorithm for detection and prediction of depression using paralinguistic speech characteristics (PSCs) - Differences in PSCs in neutral vs. depression-related speech probes - Effect of reappraisal-training with (experimental group) or without (control group) PSC feedback on depressed mood Measures: - SCID - HRSD - BDI-II - PHQ-9 - BSI Study design: -t0: Interviews, questionnaires, speech probes; -mobile assessment: 2 weeks of assessment of speech probes via EMA (ecological momentary assessment) -t1: questionnaires and reappraisal-training (2 weeks after t0) -t2: 1-month follow-up -t3: 3-month follow-up -t4: 6-month follow-up
Study Design
- Purpose:
- Treatment
- Allocation:
- Randomized controlled study
- Control:
-
- Active control (effective treatment of control group)
- Phase:
- N/A
- Study type:
- Interventional
- Mechanism of allocation concealment:
- No Entry
- Blinding:
- Yes
- Assignment:
- Parallel
- Sequence generation:
- No Entry
- Who is blinded:
-
- Assessor
- Data analyst
Recruitment
- Recruitment Status:
- Recruiting complete, study complete
- Reason if recruiting stopped or withdrawn:
- No Entry
Recruitment Locations
- Recruitment countries:
-
- Germany
- Number of study centers:
- Monocenter study
- Recruitment location(s):
-
- Other Lehrstuhl für Klinische Psychologie und Psychotherapie, Universität Erlangen-Nuernberg Erlangen
Recruitment period and number of participants
- Planned study start date:
- 2021-01-25
- Actual study start date:
- 2020-09-08
- Planned study completion date:
- No Entry
- Actual Study Completion Date:
- 2023-04-17
- Target Sample Size:
- 135
- Final Sample Size:
- 144
Inclusion Criteria
- Sex:
- All
- Minimum Age:
- 18 Years
- Maximum Age:
- 69 Years
- Additional Inclusion Criteria:
- - sufficient German language skills - willingness to provide informed consent - Non-depressed: the absence of an MDD diagnosis and no significant subthreshold symptoms of depression; subthreshold: the absence of an MDD diagnosis but presence of significant subthreshold symptoms of depression; clinically depressed: the diagnosis of major depression
Exclusion Criteria
- high risk of suicide - psychosis - bipolar disorder - substance use disorder within last 6 months - already in psychotherapeutic treatment
Addresses
Primary Sponsor
- Address:
- Lehrstuhl für Klinische Psychologie und Psychotherapie Friedrich-Alexander Universität Erlangen-NürnbergNägelsbachstr. 25a91052 ErlangenGermany
- Telephone:
- No Entry
- Fax:
- No Entry
- Contact per E-Mail:
- Contact per E-Mail
- URL:
- No Entry
- Investigator Sponsored/Initiated Trial (IST/IIT):
- Yes
Contact for Scientific Queries
- Address:
- Lehrstuhl für Klinische Psychologie und Psychotherapie, Universität Erlangen-NuernbergProf. Dr. Matthias BerkingNägelsbachstr. 25a91052 ErlangenGermany
- Telephone:
- +49/9131/8567575
- Fax:
- No Entry
- Contact per E-Mail:
- Contact per E-Mail
- URL:
- http://www.psych1.phil.fau.de
Contact for Public Queries
- Address:
- Lehrstuhl für Klinische Psychologie und Psychotherapie, Universität Erlangen-NuernbergProf. Dr. Matthias BerkingNägelsbachstr. 25a91052 ErlangenGermany
- Telephone:
- +49/9131/8567575
- Fax:
- No Entry
- Contact per E-Mail:
- Contact per E-Mail
- URL:
- http://www.psych1.phil.uni-erlangen.de/
Principal Investigator
- Address:
- Lehrstuhl für Klinische Psychologie und Psychotherapie, Universität Erlangen-NuernbergProf. Dr. Matthias BerkingNägelsbachstr. 25a91052 ErlangenGermany
- Telephone:
- +49/9131/8567575
- Fax:
- No Entry
- Contact per E-Mail:
- Contact per E-Mail
- URL:
- http://www.psych1.phil.fau.de
Sources of Monetary or Material Support
Public funding institutions financed by tax money/Government funding body (German Research Foundation (DFG), Federal Ministry of Education and Research (BMBF), etc.)
- Address:
- Deutsche ForschungsgemeinschaftKennedyallee 4053175 BonnGermany
- Telephone:
- No Entry
- Fax:
- No Entry
- Contact per E-Mail:
- Contact per E-Mail
- URL:
- http://www.dfg.de
Ethics Committee
Address Ethics Committee
- Address:
- Ethik-Kommission der Medizinischen Fakultät der Universität Erlangen-NürnbergKrankenhausstr. 1291054 ErlangenGermany
- Telephone:
- +40-9131-8522270
- Fax:
- +49-9131-8526021
- Contact per E-Mail:
- Contact per E-Mail
- URL:
- No Entry
Vote of leading Ethics Committee
- Vote of leading Ethics Committee
- Date of ethics committee application:
- 2018-02-06
- Ethics committee number:
- 73_18 B
- Vote of the Ethics Committee:
- Approved
- Date of the vote:
- 2018-02-20
Further identification numbers
- Other primary registry ID:
- No Entry
- EudraCT Number:
- No Entry
IPD - Individual Participant Data
- Do you plan to make participant-related data (IPD) available to other researchers in an anonymized form?:
- No
- IPD Sharing Plan:
- No Entry
Study protocol and other study documents
- Study protocols:
- No Entry
- Study abstract:
- No Entry
- Other study documents:
- No Entry
- Background literature:
- No Entry
- Related DRKS studies:
- No Entry
Publication of study results
- Planned publication:
- No Entry
- Publikationen/Studienergebnisse:
- No Entry
- Date of first publication of study results:
- No Entry
- DRKS entry published for the first time with results:
- No Entry
Basic reporting
- Basic Reporting / Results tables:
- No Entry
- Brief summary of results:
- No Entry