Investigation of the effects of cognitive states on sensory gating and motor output
Organizational Data
- DRKS-ID:
- DRKS00016909
- Recruitment Status:
- Recruiting ongoing
- Date of registration in DRKS:
- 2019-12-17
- Last update in DRKS:
- 2019-12-17
- Registration type:
- Retrospective
Acronym/abbreviation of the study
No Entry
URL of the study
No Entry
Brief summary in lay language
The aim of this project is to investigate the influence of sensory perception (i.e. Vision, Hearing and Touch) on motor processes, that means different movement patterns. Specifically we are interested how different cognitive states, for example Fatigue or Motivation affects the coupling between sensory perception and motor processes. We hope that by understanding the brain processes in healthy participants provide us with new methods for the future treatment of patients, for example after stroke.
Brief summary in scientific language
Reinstating the mechanisms of sensory processing and motor control is an important goal to advance treatment of neurological and neuropsychiatric diseases which are often associated with a loss of sensorimotor function. However, before one can design such therapies, in depth knowledge regarding the mechanisms governing sensory processing and motor control in healthy human subjects is required. In particular, little is known about how the current cognitive state (e.g. amount of fatigue or motivation) affects the integration of sensory information into a motor command. To fill this gap of knowledge, we will therefore investigate how integration of sensory information (i.e. vision, audition, somatosensation) shapes motor output and more importantly how this integration is affected by the current cognitive state (i.e. motivation or fatigue). We will use a multimodal approach to the solve this problem, i.e. we will combine neuroimaging methods (MRI, EEG) as well as non-invasive brain stimulation methods (NIBS; i.e. TMS, tCS) and peripheral nerve stimulation (PNS) with behavioural tests.
Health condition or problem studied
- Free text:
- Basic research in healthy participants
- Free text:
- Healthy participants
- Healthy volunteers:
- Yes
Interventions, Observational Groups
- Arm 1:
- The project involves neurophysiological measurements (e.g. fMRI, EEG and EMG) as well as non-invasive brain stimulation (e.g. TMS, tCS) during behavioural tests (e.g. sensorimotor and cognitive tasks).
Endpoints
- Primary outcome:
- Electrophysiological markers of brain activity as measured with EEG (Electroencephalography). BOLD (blood oxygenation level dependent) signal changes as measured with fMRI (Functional magnetic resonance imaging). Muscle activity as measured with EMG (Electromyography). Performance on behavioural tasks (accuracy, reaction time, and others). Eye and motion tracking measures. The planned end date of the study is 1. September 2024.
- Secondary outcome:
- Not applicable
Study Design
- Purpose:
- Basic research/physiological study
- Retrospective/prospective:
- No Entry
- Study type:
- Non-interventional
- Longitudinal/cross-sectional:
- No Entry
- Study type non-interventional:
- No Entry
Recruitment
- Recruitment Status:
- Recruiting ongoing
- Reason if recruiting stopped or withdrawn:
- No Entry
Recruitment Locations
- Recruitment countries:
-
- Switzerland
- Number of study centers:
- Monocenter study
- Recruitment location(s):
-
- Other Eidgenössische Technische Hochschule Zürich Zürich
Recruitment period and number of participants
- Planned study start date:
- 2018-09-01
- Actual study start date:
- 2018-09-01
- Planned study completion date:
- No Entry
- Actual Study Completion Date:
- No Entry
- Target Sample Size:
- 750
- Final Sample Size:
- No Entry
Inclusion Criteria
- Sex:
- All
- Minimum Age:
- 18 Years
- Maximum Age:
- 65 Years
- Additional Inclusion Criteria:
- Healthy participants Age 18 – 65 years Normal physical and mental health Normal or corrected to normal vision
Exclusion Criteria
Known history of neurological, musculoskeletal or neuromuscular disorders. Pregnancy. Participants with metal implants in their body including pacemakers, or electronically/magnetically/mechanically activated implants.
Addresses
Primary Sponsor
- Address:
- NCM-Lab, ETH ZürichProf. Dr. Nicole WenderothAuguste-Piccard-Hof 18093 ZürichSwitzerland
- Telephone:
- +41 44 635 61 55
- Fax:
- No Entry
- Contact per E-Mail:
- Contact per E-Mail
- URL:
- No Entry
- Investigator Sponsored/Initiated Trial (IST/IIT):
- Yes
Contact for Scientific Queries
- Address:
- NCM-Lab, ETH ZürichProf. Dr. Nicole WenderothAugust-Piccard-Hof 18093 ZürichSwitzerland
- Telephone:
- +41 44 635 61 55
- Fax:
- No Entry
- Contact per E-Mail:
- Contact per E-Mail
- URL:
- No Entry
Contact for Public Queries
- Address:
- NCM-Lab, ETH ZürichProf. Dr. Nicole WenderothAuguste-Piccard-Hof 18093 ZürichSwitzerland
- Telephone:
- +41 44 635 61 55
- Fax:
- No Entry
- Contact per E-Mail:
- Contact per E-Mail
- URL:
- No Entry
Principal Investigator
- Address:
- NCM-Lab, ETH ZürichProf. Dr. Nicole WenderothAugust-Piccard-Hof 18093 ZürichSwitzerland
- Telephone:
- +41 44 635 61 55
- Fax:
- No Entry
- Contact per E-Mail:
- Contact per E-Mail
- URL:
- No Entry
Sources of Monetary or Material Support
Institutional budget, no external funding (budget of sponsor/PI)
- Address:
- NCM-Lab, ETH ZürichAuguste-Piccard-Hof 18093 ZürichSwitzerland
- Telephone:
- +41 44 635 61 55
- Fax:
- No Entry
- Contact per E-Mail:
- Contact per E-Mail
- URL:
- No Entry
Ethics Committee
Address Ethics Committee
- Address:
- Kantonale Ethikkommission Zürich [Kantonale Ethikkommission Zürich ]Stampfenbachstrasse 121CH-8090 ZürichSwitzerland
- Telephone:
- No Entry
- Fax:
- No Entry
- Contact per E-Mail:
- Contact per E-Mail
- URL:
- http://www.kek.zh.ch/internet/gesundheitsdirektion/kek/de/home.html
Vote of leading Ethics Committee
- Vote of leading Ethics Committee
- Date of ethics committee application:
- 2018-06-20
- Ethics committee number:
- BASEC-Nr. 2018-01078
- Vote of the Ethics Committee:
- Approved
- Date of the vote:
- 2018-08-23
Further identification numbers
- Other primary registry ID:
- No Entry
- EudraCT Number:
- No Entry
IPD - Individual Participant Data
- Do you plan to make participant-related data (IPD) available to other researchers in an anonymized form?:
- Yes
- IPD Sharing Plan:
- Anonymised measurement data can only be made available to other research groups if participants sign the corresponding separate written consent form for further data use. The written consent allows both the sharing of anonymized data upon request as well as upload of the data to scientific databases. This agreement does not expire.
Study protocol and other study documents
- Study protocols:
- No Entry
- Study abstract:
- No Entry
- Other study documents:
- No Entry
- Background literature:
- No Entry
- Related DRKS studies:
- No Entry
Publication of study results
- Planned publication:
- No Entry
- Publikationen/Studienergebnisse:
- No Entry
- Date of first publication of study results:
- No Entry
- DRKS entry published for the first time with results:
- No Entry
Basic reporting
- Basic Reporting / Results tables:
- No Entry
- Brief summary of results:
- No Entry