German Clinical Trials Register

Sex:

All

All subjects: 1. Haematological or biochemical parameters that are outside the normal range and are considered clinically significant by the investigator. 2. History of alcohol or drug abuse/dependence 3. History of major allergic reactions 4. History of epilepsy 5. History of electroconvulsive therapy 6. Any significant disease or unstable medical condition (e.g. unstable angina, myocardial infarction or coronary revascularization in the preceding 12 months, cardiac failure, chronic renal failure, chronic hepatic disease, severe pulmonary disease, blood disorders, poorly controlled diabetes, chronic infection) 7. Criteria which in the opinion of the investigator preclude participation for scientific reasons, for reasons of compliance, or for reasons of the volunteer’s safety 8. Participants in whom magnetic resonance imaging (MRI) is contraindicated. 9. Patient / Volunteer is in custody by order of an authority or a court of law 10. Exclusion periods from other studies or simultaneous participation in other clinical studies 11. Patient / Volunteer has received another investigational drug in the preceding 2 months 12. Previous enrollment in this study 13. Active Smokers 14. Interuption of central acting drugs less than 5 to 10 half lifes is not possible 15. Inadequate collateral circulation of the hand AD patients: 1. History, physical or imaging findings of other neurological illness apart from AD such as cerebrovascular disease, inflammatory or infectious disease and other degenerative diseases or other types of dementia such as fronto-temporal lobe dementia or Lewy body disease. Healthy volunteers: 1. Clinical significant abnormal physical examination 2. Evidence of any significant psychiatric or neurological illness from history, clinical or para – clinical findings 3. History, physical or imaging findings of any significant neurological illness such as cerebrovascular disease, inflammatory or infectious disease and other neurodegenerative diseases 4. Previous significant occupational exposure to ionizing radiation or in whom, within the last 10 years, radioactive substances or when ionizing radiation was applied for the purposes of research. (According to § 24 Abs. 1 Nr. 6 StrlSchV / § 28b Abs. 1 Nr. 6 RöV)